Cisplatin and electrolyte abnormalities

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August undefined, 2024

WebAbstract Cisplatin is a widely used platinum‐based chemotherapy agent. Its common adverse effects are neuropathy, nephrotoxicity, electrolyte abnormality, and rarely causing thrombotic vascular toxicity. We present a patient known to have small‐cell lung cancer who developed ischemic cerebrovascular accident (CVA) after receiving ... WebAug 18, 2024 · Mannitol, given as a hypertonic solution, is primarily used in the treatment of cerebral edema and glaucoma. Although generally well tolerated, a variety of fluid, electrolyte, and kidney complications can occur if the patient is not carefully monitored. (See "Evaluation and management of elevated intracranial pressure in adults", section on ...

Incidence and spectrum of electrolyte disturbances in cisplatin bas…

WebOct 19, 2024 · Severe electrolyte abnormalities during cisplatin were associated with having 2–6-month CKD or hypertension (adjusted odds ratio (AdjOR) [95% CI]: 2.65 [1.04–6.74]). Having both AKI and severe electrolyte abnormalities was associated with 2–6-month hypertension (AdjOR [95% CI]: 3.64 [1.05–12.62]). Conclusions WebA slight electrolyte imbalance may not cause noticeable changes. When problems occur, you may experience: Confusion and irritability. Diarrhea or constipation. Fatigue. Headaches. Irregular or fast heart rate (arrhythmia). Muscle cramps, muscle spasms or weakness. Nausea and vomiting. Numbness or tingling in limbs, fingers and toes. how does a heat pump hvac system work

Lithium concentrations during cisplatin-based chemotherapy …

WebJul 18, 2024 · Cisplatin causes hypomagnesemia in a dose-dependent fashion and affects up to 90% of patients if no preventive measures are taken (see Section 5 below). 79 The etiology of cisplatin-induced hypomagnesemia is not completely understood; renal Mg loss is the primary mechanism, but gastrointestinal losses have also been reported. 80 … WebDec 15, 2024 · An electrolyte imbalance occurs when your body’s mineral levels are too high or too low. This can negatively affect vital body systems. Electrolytes must be evenly balanced for your body to... WebSep 1, 2024 · Cisplatin for injectioncan cause dose-related peripheral neuropathy that becomes more severe with repeated courses of the drug. Neurologic symptoms have … how does a heat pump geyser work

Complications of mannitol therapy - UpToDate

Electrolyte Imbalance: Types, Symptoms, Causes & Treatment

WebCertain medications may cause an electrolyte imbalance such as: Chemotherapy drugs (cisplatin) Diuretics (furosemide [Lasix] or bumetanide [Bumex]) Antibiotics (amphotericin B) Corticosteroids (hydrocortisone) Symptoms of Electrolyte Imbalance: As described, an electrolyte imbalance may create a number of symptoms. WebNov 1, 2024 · Vaughn E. Dobalian Abstract and Figures Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia,... how does a heat pump work pdfWebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium wasting. … how does a heat recovery ventilator work

"WebJun 24, 2024 · Electrolyte abnormalities (hypokalemia, hypophosphatemia, and hypomagnesemia) Electrolyte abnormalities were defined as ≥ grade 1 hypokalemia, … " - Cisplatin and electrolyte abnormalities

Cisplatin and electrolyte abnormalities

WebMay 1, 2024 · The most common diagnoses were central nervous system tumors (58 [36%]), neuroblastoma (43 [27%]), and osteosarcoma (33 [21%]). Acute kidney injury (by serum creatinine level increase) occurred in 48 of 159 patients (30%) at early cisplatin infusions and 23 of 143 patients (16%) at late cisplatin infusions. WebMay 24, 2006 · This drug should be considered among the possible causes of chronic unexplained electrolyte disorders. Cisplatin is a well-known nephrotoxic antineoplastic …

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WebJan 1, 2015 · Similarly, hypomagnesemia exclusive to chemotherapeutic agents like cisplatin, ifosfamide, and cetuximab is only seen in cancer patients. This chapter describes the frequency of the most commonly observed electrolyte disorders in the oncology patient and delves into the unique cancer- or chemotherapy-related etiology of these … WebUse Caution/Monitor. Comment: Coadministration with medications that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure, arrhythmias, and renal impairment. ... Additive: etoposide w/ cisplatin & KCl(?), imipenem-cilastatin (may be used for shorter periods), meropenem (may be used for shorter periods) ...

WebMar 1, 2024 · A case of an elderly male presenting with significant recurrent hyponatremia, and prerenal azotemia, with recent exposure to cisplatin along with significant hypovolemia and urinary loss of sodium is reported. Cisplatin is a well‐known chemotherapeutic agent that can be associated with hyponatremia. It is known to be associated with a multitude … http://www.ejmanager.com/mnstemps/93/93-1446132625.pdf#:~:text=The%20most%20common%20electrolyte%20abnormality%20associated%20with%20cisplatin,the%20incidence%20of%20which%20varies%20significantly%20between%20studies.

WebJun 26, 2024 · Nephrotoxicity-indicated by high serum creatinine, low estimated glomerular filtration rate (eGFR), and/or electrolyte abnormalities, appears in about one-third of … WebApr 12, 2024 · In cancer patients, electrolyte disorders are frequent due to tubular functional abnormalities related to chemotherapeutic drugs, the TLS and the impaired secretion of antidiuretic hormone ... As previously described, also the cisplatin can induce electrolyte imbalances. In this case, the standard approach to avoid cisplatin-induced ...

WebFrequent grade 3 or 4 adverse events included fatigue, dyspnea, leukopenia, thrombocytopenia, and electrolyte abnormalities. No objective responses were observed; 5 (50%) of 10 patients treated at the MTD had stable disease. Pharmacokinetics indicated an oral triapine bioavailability of 88%.

WebJan 17, 2015 · In this research, we focused only on electrolyte abnormalities following cisplatin toxicity, to predict electrolyte abnormalities occurred in dogs treated with cisplatin. The present study was carried out to evaluate renal function of dogs administered with cisplatin 0.75 mg/kg/day for 5 consecutive days with assaying of electrolytes and … how does a heat rash go awayWebMay 18, 2024 · Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, … how does a heat pump system workWebPlatelets <50000 Neutrophils <500 Renal Impairment CrCl 41-59 mL/min: 250 mg/m² IV on day 1 CrCl 16-40 mL/min: 200 mg/m² IV on day 1 CrCl <15 mL/min: Not recommended Hepatic Impairment Dose... how does a heat pump work physicsWebJun 24, 2024 · Cisplatin-induced nephrotoxicity mainly manifests as kidney tubular injury leading to electrolyte disturbances manifested as hypomagnesemia, hypokalemia, and hypophosphatemia and/or increased serum creatinine (occurring more than 7 days after treatment initiation) and decreased glomerular filtration rate [ 8, 9 ]. how does a heat sealer workWebDec 9, 2024 · Electrolyte disorders are very common conditions in cancer patients. They mainly concern changes in serum sodium, potassium, calcium, and magnesium levels. In … phormium green dwarf nzWebHypomagnesemia may cause nausea, vomiting, sleepiness, weakness, personality changes, muscle spasms, tremors, and loss of appetite. If severe, hypomagnesemia can cause seizures Seizure Disorders In seizure disorders, the brain's electrical activity is periodically disturbed, resulting in some degree of temporary brain dysfunction. Many … phormium hardiness how does a heat pump tumble dryer work uk