Mitf phosphorylation
Web15 mei 2024 · MITF, TFEB, and TFE3 overexpression was also observed in pancreatic adenoductal carcinoma, where they appear to support tumor growth via the induction of autophagy (Perera et al, 2015). MITF is an … Web1 aug. 2015 · Thus, the activity of Mitf as a transcription factor appeared to promote its own cytoplasmic sequestration, a phenomenon consistent with increased TORC1 activity in …
Mitf phosphorylation
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WebPhosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence. Microphthalmia-associated transcription factor (MITF) … Web17 dec. 2024 · MITF has three recognized phosphorylation sites: Ser73 (phosphorylated by ERK) , and Ser298 and Ser409 (phosphorylated by GSK3β). MITF phosphorylated at …
Web13 jan. 2024 · MiTF phosphorylation generally enhances its activity, even though double phosphorylation at Ser73 and Ser409 promotes its proteasome-dependent degradation … Web31 dec. 2024 · GSK3β phosphorylates MITF at 3 C-terminal phosphorylation sites, targeting MITF for proteasomal degradation ; therefore, inhibition of AKT by ACF would result in decreased MITF protein stability. On the other hand, we observed that ACF reduced the phosphorylation of RSK2, a kinase that is controlled through its phosphorylation …
WebWe show that mice that carry a BAC transgene where single-amino-acid substitutions have been made in the Mitf gene rescue the phenotype of the loss-of-function mutations in Mitf. This may indicate that. signaling from KIT to MITF affects other phospho-acceptor sites in MITF or that alternative sites can be phosphorylated when Set73 and Ser409 have been … Web27 nov. 2024 · Effects of SIP MITF and Phosphorylation of CREB Protein Expressions in Forskolin-Stimulated B16F10 Cells. It was proven that the TYR gene family proteins …
Web15 dec. 2016 · Combination therapy targeting the MAPK pathway and GPNMB in BRAF-mutant melanoma. BRAF mutations (*) are present in approximately 50% of melanomas, which constitutively activate the MAPK pathway. Downstream ERK activation leads to MITF phosphorylation, resulting in decreased MITF protein stability and cytoplasmic retention.
Web4 jun. 2024 · In this frame, MITF modulates not only catabolic pathways, like autophagy, but also mitochondrial biogenesis and oxidative phosphorylation [67, 68]. MITF regulation … leitor mifare mf-easy v2.1.24 saida w2Web11 apr. 2024 · After blocking, the cytoslide was incubated with a primary antibody [Phospho-JNK (Cell Signaling, 9255 S) or Phospho-MITF (Millipore Sigma, SAB4503940)] in a buffer containing PBST and 0.1% BSA ... leitor honeywell configurarWeb3 jun. 2013 · MITF phosphorylation upon AMPK inhibition is dependent on active ERK. Key kinases responsible for MITF phosphorylation are the mitogen-activated protein … leitor sem fio honeywellWebA heart specific isoform of MITF is a major regulator of cardiac growth and hypertrophy responsible for heart growth and for the physiological response of the cardiomyocytes to … leitor sped fiscalWebThe microphthalmia-associated transcription factor (Mitf) has emerged as an important model for gene regulation in eukaryotic organisms. In vertebrates, it regulates the … leitor elgin flash 2 manualWeb6 jan. 2024 · Early studies indicated that the six major human MITF isoforms originated from a combination of multiple alternative splicing events and promoter usage, resulting in the … leitor hid r10Web2 dagen geleden · The other two transcription factors in the MiT/TFE family, TFE3 and MITF, ... Liu L. Phosphorylation and acetylation modifications of FOXO3a: Independently or synergistically? leitor jetway jl-200