Web14. apr 2024 · Following the binding of MDC1 (mediator of DNA damage checkpoint protein 1) to γH2AX, TOPBP1-ATR is further activated and confined to the sex body and promotes the γH2AX signal spread to the protruding loops of the chromatin at the mid-pachytene stage (Ichijima et al., 2011; ElInati et al., 2024). WebTopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome …

RCSB PDB - 3UEN: Crystal structure of TopBP1 BRCT4/5 domains

Web7. nov 2024 · TOPBP1 is essential for localization to the X chromosome of silencing “sensors,” including BRCA1, and effectors, including ATR, γH2AFX, and canonical … Web11. jan 2024 · In this report, we demonstrate that HPV16 and HPV11 E2 protein expression is dependent upon TopBP1 interaction in keratinocytes interacting with fibroblasts, which recapitulate stromal interactions in culture. The degradation of 16E2 promotes HPV16 genome integration, therefore the E2-TopBP1 interaction is critical during the viral life … can you invest in the boring company

Structure and function of the Rad9-binding region of the DNA …

DNA topoisomerase 2-binding protein 1 (TOPBP1) is a scaffold protein that in humans is encoded by the TOPBP1 gene. TOPBP1 was first identified as a protein binding partner of DNA topoisomerase-IIβ by a yeast 2-hybrid screen, giving it its name. TOPBP1 is involved in a variety of nuclear specific … Zobraziť viac BRCT domains The TOPBP1 gene encodes a scaffold protein which facilitates interactions between different proteins at specific times and locations. It accomplishes these interactions with … Zobraziť viac • DNA damage repair • Ataxia-telangiectasia mutated and RAD3-related (ATR) • BRCA1 • DNA replication Zobraziť viac DNA damage repair TOPBP1 was first identified as a DNA damage protein through its association with Zobraziť viac Cancer Changes in TOPBP1 gene expression are associated with breast cancer, glioblastoma Zobraziť viac • Yamane K, Tsuruo T (September 1999). "Conserved BRCT regions of TopBP1 and of the tumor suppressor BRCA1 bind strand breaks and termini of DNA" Zobraziť viac Web1. feb 2016 · Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human … Web1. okt 2014 · The TopBP1-family of proteins has emerged as playing key roles in a diverse range of cellular pathways. These include the initiation of DNA replication and the activation of the DNA-dependant checkpoints, where mechanistic insights are beginning to elucidate the molecular details. The function of TopBP1 in the regulation of DNA repair and gene ... can you invest in the s\u0026p 500 on robinhood